1. DNA damage: association of PARP-1 with DNA repair factors such as PCNA and p21 and its modulation by acetylation and phosphorylation (Ennio Prosperi, in collaboration with Olga Lavrik, Novosibirsk, Russia).
2. Cell death: characterization of poly(ADP-ribosylation) role in different cell death paradigms, including apoptosis, caspase-independent pathways, parthanatos, necroptosis and autophagy.
3. Validation of PAR level as a new biomarkers of cellular stress: PAR accumulation correlates with DNA damage and stress conditions.