1. PARP-1 in DNA damage response- The rapid synthesis of PAR at the DNA lesion site establishes a unique signal that coordinates the relaxation of chromatin and the signal transduction of the damage. Looking at the proteins whose level increases in DNA damage response, our attention was focused on the phosphoprotein Che-1, showing that Che-1 poly ADP-ribosylation is indispensable for its nuclear accumulation.
2. PARP-1 in cancer as target for therapy or stratification-risk marker – PARP-1 is emerging as a master regulator of epigenetic changes broadly connected to cancer etiology and progression. Our actual research concerns the role of PARP-1 in regulating the levels and the activity of some important transcriptional factors which orchestrate the Epithelial-Mesenchymal Transition process (EMT), an embryonic key developmental program that is often activated during cancer invasion and metastasis.