VITTORIA SPINA PURRELLO

1. Expression of PARP family genes and proteins in mammalian primary and established tumor cell lines, at steady state and under  proinflammatory conditions. Role of PARP’s inhibitors and antioxidant molecules in cell death processes.

2. PARP’s involvement in diabetes mellitus (DM2) analyzed by using murine pancreatic cell lines.

3. DNA-independent PARP-1 activation in primary microvascular endothelial cells  from bovine brain (BBECs).